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1.
Arq. bras. oftalmol ; 82(5): 372-376, Sept.-Oct. 2019. tab, graf
Article in English | LILACS | ID: biblio-1019436

ABSTRACT

ABSTRACT Purpose: We evaluated the role of the conjunctival flap rotation technique using 5-fluorouracil and adjuvant therapy with topical cyclosporine A at 0.05% during short pre- and postoperative periods for the prevention of primary pterygium recurrence. Methods: In this prospective study, 76 patients with primary pterygium (76 eyes) were categorized into two groups: the control group with 31 patients who did not receive cyclosporine treatment, and the cyclosporine group with 45 patients who received topical cyclosporine A (0.05%) twice a day, for 10 days before and 10 days after the pterygium excision operations. Patients were examined for disease recurrence, side effects, and complications at 10 and 21 days, and at 2 and 6 months after the operation. Data on demography, systemic diseases, and ophthalmologic histories were obtained from all patients, and these data were analyzed using descriptive statistics involving the absolute and relative percentages of frequency distribution. Goodman test was used for contrasts among multinomial populations to study the association between cyclosporine A and recurrence. Results: Most patients were between 30 and 60 years of age, and 67.1% were women. We confirmed a higher recurrence in patients with occupational sunlight exposure. The cyclosporine A used topically 10 days before and 10 days after the pterygium removal did not significantly reduce the recurrence of the pterygium. Conclusion: Topical 0.05% cyclosporine A when used for 10 days before and 10 days after the pterygium removal does not prevent or reduce the recurrence of primary pterygium.


RESUMO Objetivo: Avaliamos os resultados da técnica de rotação de retalho conjuntival com uso de 5-fluorouracil e terapia adjuvante com ciclosporina A tópica a 0,05%, usada no pré e pós-operatório por curto período, quanto à prevenção da recidiva do pterígio primário Métodos: Estudo prospectivo, com 76 pacientes portadores de pterígio primário (76 olhos), divididos em dois grupos: controle com 31 pacientes que não receberam tratamento com ciclosporina e grupo ciclosporina com 45 pacientes que receberam ciclosporina tópica A (0,05%) duas vezes ao dia, por 10 dias antes e 10 dias após a cirurgia de excisão do pterígio. Os pacientes foram avaliados quanto à recorrência, efeitos colaterais e complicações com 10, 21 dias, 2 e 6 meses de pós-operatório. Dados demográficos, doenças sistêmicas e histórico oftalmológico foram coletados de todos os pacientes e esses dados foram analisados por meio de estatística descritiva envolvendo o percentual absoluto e relativo de distribuição de frequência. O teste de Goodman para contrastes entre populações multinomiais foi utilizado para o estudo da associação entre a ciclosporina A e a recorrência Resultados: A maioria dos pacientes tinha entre 30 e 60 anos e 67,1% eram mulheres. Confirmamos uma maior recorrência em pacientes com exposição ocupacional ao sol. A ciclosporina A tópica utilizada 10 dias antes e 10 dias após a remoção do pterígio não reduziu significativamente a sua recorrência Conclusão: A ciclosporina A tópica a 0,05% quando utilizada por 10 dias no pré e 10 dias no pós-operatório, não previne ou reduz a recidiva do pterígio primário significativamente.


Subject(s)
Humans , Male , Female , Adult , Middle Aged , Young Adult , Pterygium/prevention & control , Cyclosporine/administration & dosage , Conjunctiva/abnormalities , Immunosuppressive Agents/administration & dosage , Ophthalmic Solutions/administration & dosage , Postoperative Care , Recurrence , Surgical Flaps , Preoperative Care , Pterygium/surgery , Pterygium/drug therapy , Prospective Studies , Combined Modality Therapy , Conjunctiva/surgery , Corneal Diseases/drug therapy , Fluorouracil/therapeutic use
2.
Arq. bras. oftalmol ; 80(2): 131-136, Mar.-Apr. 2017. tab, graf
Article in English | LILACS | ID: biblio-838789

ABSTRACT

ABSTRACT In this systematic review, we evaluated studies involving adjuvant and primary topical treatment for ocular surface squamous neoplasia (OSSN). The findings were: (i) adjuvant 5-fluorouracil (5-FU) reduces the risk of relapse after surgical excision with mild side effects [level Ib, grade of recommendation (GR) A]. (ii) Primary topical mitomycin (MMC) produces a high rate of complete response, low recurrence rate, and mild side effects (level Ib, GR A). (iii) Primary chemotherapy versus adjuvant chemotherapy produce similar rates of recurrence, with no significant difference (level IIb, GR B). (iv) Adjuvant 5-FU versus MMC showed no significant differences, with mild side effects in both groups and a better toxicity profile for MMC (level III, GR C). (v) Primary topical 5-FU versus MMC versus interferon (IFN) showed similar rates of tumor recurrence, mild side effects for all drugs, and more severe side effects in the 5-FU arm, followed successively by MMC and IFN (level III, GR C).


RESUMO Revisão sistemática envolvendo estudos sobre o tratamento adjuvante e tratamento tópico primário para a neoplasia escamosa da superfície ocular. Os resultados foram: (i) 5-fluorouracil adjuvante reduziu o risco de recidiva após a excisão cirúrgica com efeitos colaterais leves (nível Ib, Grau de recomendação (GR) A). (ii) Mitomicina tópica primária produziu uma alta taxa de resposta completa, baixa taxa de recorrência e efeitos colaterais leves (nível Ib, GR A). (iii) Quimioterapia primária versus adjuvante produz taxas semelhantes de recorrência (nível IIb, GR B). (iv) 5- 5-FU versus mitomicina adjuvante não mostrou diferenças significativas nas taxas de recorrencia, com efeitos coalterais leves em ambos os grupos e melhor perfil de toxicidade para mitomicina (nível III, GR C). (v) 5- 5-FU tópico primário versus mitomicina ou interferon (INF) apresentam taxa similar de recorrência, com efeito colateral leve, mas com maior incidencia no braço 5- 5-FU, seguido pela Mitomicina e IFN (nível III, GR C).


Subject(s)
Humans , Carcinoma, Squamous Cell/drug therapy , Mitomycin/therapeutic use , Corneal Diseases/drug therapy , Eye Neoplasms/drug therapy , Fluorouracil/therapeutic use , Recurrence , Recombinant Proteins/therapeutic use , Administration, Topical , Chemotherapy, Adjuvant/methods , Conjunctival Neoplasms/drug therapy , Conjunctival Neoplasms/therapy , Corneal Diseases/therapy , Eye Neoplasms/therapy , Interferon alpha-2 , Antineoplastic Agents/therapeutic use
3.
Rev. bras. oftalmol ; 75(5): 391-395, sept.-out. 2016. tab
Article in Portuguese | LILACS | ID: lil-798072

ABSTRACT

RESUMO Objetivo: Avaliar a segurança e eficácia de três técnicas distintas para o tratamento de neoplasia intraepitelial córneo-conjuntival. Métodos: Vinte e seis pacientes, 11 mulheres e 15 homens, com idade entre 32 e 88 anos (média 64,84 anos), atendidos entre 1999 e 2014, foram incluídos neste estudo. Todos os pacientes foram submetidos à exérese da lesão com margem de segurança de 4mm e crioterapia a 2mm do limbo. Conforme o tratamento complementar, os pacientes foram divididos em três grupos: Grupo 1 (8 olhos): recobrimento conjuntival e 2 ciclos de mitomicina C 0,02% (MMC) 4x/dia por 10 dias, com intervalo de 30 dias entre os ciclos. Grupo 2 (9 olhos): recobrimento com membrana amniótica e 3 ciclos de MMC 3x/dia por 10 dias, com intervalo de 10 dias entre o 1º e o 2º ciclo e 30 dias entre 2º e o 3º ciclo. Grupo 3 (9 olhos): recobrimento com membrana amniótica sem o uso de MMC. O acompanhamento dos pacientes variou de 3 meses a 14 anos (média: 4 anos). Resultados: Vinte e três pacientes apresentaram erradicação da lesão com um único tratamento. Três pacientes do Grupo 3 apresentaram recidiva da lesão após 3 meses, 6 meses e 1 ano do tratamento. Dois deles foram retratados pela técnica 1, sem nova recidiva após seguimento de 3 e 4 anos; o outro paciente foi submetido à enucleação. Não foram observados efeitos colaterais relacionados ao uso da mitomicina C durante o seguimento. Conclusão: Após exérese da lesão e crioterapia, os pacientes tratados com recobrimento conjuntival ou membrana amniótica associado à mitomicina C mostraram tendência a resultados mais eficazes.


ABSTRACT Purpose: To evaluate the safety and efficacy of three different techniques for the treatment of conjunctival-corneal intraepithelial neoplasia. Methods: Twenty-six eyes of 26 patients, 11 women and 15 men were included in a nonrandomized, retrospective, observational case series. Mean patient age was 64 years (range, 32-88 years).All patients were treated from 1999 to 2014. Mean postoperative follow-up was 4 years (range, 3 months to 14 years). All patients underwent excision of the lesion with a 4-mm safety margin and a 2-mm from the limbus cryotherapy. As further treatment the patients were divided into three groups: Group 1 (8 eyes): conjunctival autograft and 2 cycles of mitomycin C 0.02% (MMC) eye drops, four times daily for 10 days with an interval of 30 days between cycles. Group 2 (9 eyes): amniotic membrane (AM) graft and 3 cycles of MMC eye drops, three times daily for 10 days with an interval of 10 days between the 1st and 2nd cycle and 30 days between the 2nd and 3rd cycle. Group 3 (9 eyes): AM graft without MMC eye drops. Results: After a single treatment, the lesions were eradicated in twenty-three patients. Recurrence was noted in three patients from Group 3 at 3 months, 6 months and 1 year after treatment. Two of them were retreated by the technique used in Group 1 without further recurrence; the other patient underwent enucleation. No adverse effects related to the use of mitomycin C were observed during. There were no side effects related to the use of mitomycin C during follow-up. Conclusion: After surgical excision and cryotherapy, patients treated with conjunctival or amniotic membrane graft associated with mitomycin C, showed a tendency to more effective results.


Subject(s)
Humans , Male , Female , Adult , Middle Aged , Aged , Aged, 80 and over , Carcinoma in Situ/therapy , Mitomycin/therapeutic use , Cryotherapy , Conjunctival Neoplasms/therapy , Corneal Diseases/therapy , Amnion/transplantation , Ophthalmologic Surgical Procedures/methods , Carcinoma in Situ/surgery , Carcinoma in Situ/pathology , Carcinoma in Situ/drug therapy , Prospective Studies , Follow-Up Studies , Treatment Outcome , Limbus Corneae , Combined Modality Therapy , Conjunctival Neoplasms/surgery , Conjunctival Neoplasms/pathology , Conjunctival Neoplasms/drug therapy , Corneal Diseases/surgery , Corneal Diseases/pathology , Corneal Diseases/drug therapy , Neoplasm Recurrence, Local
4.
Arq. bras. oftalmol ; 78(4): 255-256, July-Aug. 2015. ilus
Article in English | LILACS | ID: lil-759263

ABSTRACT

ABSTRACTWe report a case of primary acquired corneal melanosis without atypia associated with corneal haze in a patient with a history of limbal malignant melanoma and the effect of mitomycin-C. A 75-year-old woman with a history of limbal malignant melanoma presented with loss of vision in right eye. Corneal examination showed a patchy melanotic pigmentation with a central haze. Topical mitomycin-C improved visual acuity and corneal haze. However, the pigmented lesions persisted, and they were removed with alcohol corneal epitheliectomy. Histopathological examination demonstrated primary acquired melanosis without atypia. The lesions were successfully removed, and there were no recurrences during the follow-up period of 36 months. The association of conjunctival and corneal melanosis without atypia is a rare condition. In addition, co-existence of central corneal haze and melanosis may decrease visual acuity. Topical mitomycin-C and alcohol corneal epitheliectomy can be useful treatments in this condition.


RESUMORelatar um caso de melanose adquirida primária de córnea sem atipia, associado a haze corneano em um paciente com história de melanoma maligno de limbo e o efeito da mitomicina-C. Uma mulher de 75 anos de idade, com história de melanoma maligno do limbo apresentado com diminuição de visão no olho direito. O exame de córnea mostrou uma pigmentação melânica irregular com um haze central. O uso de mitomicina-C tópica levou à melhora da acuidade visual e da opacidade corneana. No entanto, as lesões pigmentadas persistiram e foram removidas com epiteliectomia associada ao álcool. O exame histopatológico demonstrou melanose adquirida primária sem atipia. As lesões foram removidas com êxito, e não houve recidiva durante o período de acompanhamento de 36 meses. A associação melanose sem atipia da conjuntiva e da córnea é uma condição rara. Além disso, a coexistência de haze corneano central e melanose pode diminuir a acuidade visual. O uso de mitomicina-C tópica e epiteliectomia corneana auxiliada pelo álcool podem ser tratamentos úteis nessa situação.


Subject(s)
Aged , Female , Humans , Antibiotics, Antineoplastic/therapeutic use , Corneal Diseases/drug therapy , Melanosis/drug therapy , Mitomycin/therapeutic use , Combined Modality Therapy , Conjunctival Neoplasms/complications , Corneal Diseases/etiology , Follow-Up Studies , Melanoma/complications , Melanosis/etiology , Treatment Outcome , Visual Acuity
5.
Arq. bras. oftalmol ; 77(3): 191-192, May-Jun/2014. graf
Article in English | LILACS | ID: lil-723837

ABSTRACT

We describe a case of early post-LASIK ectasia detected in the first 6 months after surgery. The patient was treated by means of intrastromal corneal crosslinking under the flap, without de-epithelialization, which resulted in a positive outcome. At the time of writing, 2 years after the procedure, the patient remained free of progression.


Descrevemos um caso de ectasia de córnea precoce após cirurgia de LASIK, detectado no primeiro semestre pós-operatório. Nós optamos tratar este paciente com "crosslinking" embaixo do "flap" , sem desepitelização com bons resultados. A paciente permaneceu sem progressão da ectasia até o momento atual, dois anos após o procedimento.


Subject(s)
Adult , Female , Humans , Corneal Diseases/drug therapy , Corneal Diseases/etiology , Keratomileusis, Laser In Situ/adverse effects , Postoperative Complications/drug therapy , Postoperative Complications/etiology , Corneal Topography , Cornea/pathology , Cornea/surgery , Dilatation, Pathologic/drug therapy , Dilatation, Pathologic/etiology , Photosensitizing Agents/administration & dosage , Riboflavin/administration & dosage , Time Factors , Treatment Outcome , Visual Acuity
6.
Indian J Ophthalmol ; 2012 Jan; 60(1): 71-72
Article in English | IMSEAR | ID: sea-138797

ABSTRACT

We report the case of a 68-year-old male who developed Descemet's membrane detachment after temporal clear corneal phacoemulsification which did not settle with air or viscoelastic injection. The Descemet's membrane was successfully reattached with restoration of 20/50 vision with the help of perfluro-n-octane liquid. To our knowledge, this is the first such case to be reported.


Subject(s)
Aged , Cataract Extraction/adverse effects , Contrast Media/administration & dosage , Corneal Diseases/drug therapy , Corneal Diseases/etiology , Descemet Membrane/pathology , Fluorocarbons/administration & dosage , Follow-Up Studies , Humans , Injections , Male , Visual Acuity
7.
Indian J Ophthalmol ; 2010 Jan; 58(1): 64-66
Article in English | IMSEAR | ID: sea-136016

ABSTRACT

We report an interesting ocular finding of bilateral multiple coin-shaped epithelial lesions along with the confocal microscopy findings in a patient following an acute attack of erythema multiforme (EM) minor. A 30-year-old male presented with a history of watering and irritation in both eyes of three days duration. He was diagnosed to have EM minor and was on oral acyclovir. Slit-lamp examination revealed multiple coin-shaped epithelial lesions. Confocal microscopy showed a corresponding conglomerate of hyper-reflective epithelial lesions. The corneal lesions resolved over six weeks with oral steroids and acyclovir. An immunological mechanism is suspected.


Subject(s)
Acute Disease , Adult , Antiviral Agents/therapeutic use , Cornea/pathology , Corneal Diseases/drug therapy , Corneal Diseases/etiology , Corneal Diseases/pathology , Diagnosis, Differential , Drug Therapy, Combination , Follow-Up Studies , Glucocorticoids/therapeutic use , Humans , Male , Microscopy, Confocal/methods , Stevens-Johnson Syndrome/complications , Stevens-Johnson Syndrome/diagnosis , Stevens-Johnson Syndrome/drug therapy
8.
Indian J Ophthalmol ; 2009 Jul; 57(4): 311-313
Article in English | IMSEAR | ID: sea-135968

ABSTRACT

The milky sap or latex of Euphorbia plant is highly toxic and an irritant to the skin and eye. This report illustrates the spectrum of ocular inflammation caused by accidental inoculation of latex of Euphorbia plant. Three patients presented with accidental ocular exposure to the milky sap of Euphorbia species of recent onset. The initial symptoms in all cases were severe burning sensation with blurring of vision. Visual acuity reduced from 20/60 to counting fingers. Clinical findings varied from kerato-conjunctivitis, mild to severe corneal edema, epithelial defects, anterior uveitis and secondary elevated intraocular pressure. All symptoms and signs had resolved by 10-14 days with active supportive medication. People who handle Euphorbia plants should wear eye protection. It is always advisable to ask the patient to bring a sample of the plant for identification.


Subject(s)
Aged, 80 and over , Corneal Diseases/drug therapy , Corneal Diseases/etiology , Corneal Edema/drug therapy , Corneal Edema/etiology , Corneal Edema/pathology , Epithelium, Corneal , Euphorbia/classification , Euphorbia/metabolism , Female , Gardening , Humans , Keratitis/drug therapy , Keratitis/etiology , Male , Middle Aged , Ocular Hypertension/drug therapy , Ocular Hypertension/etiology , Plant Exudates/adverse effects , Uveitis, Anterior/drug therapy , Uveitis, Anterior/etiology , Vision Disorders/drug therapy , Vision Disorders/etiology
9.
Arq. bras. oftalmol ; 71(6,supl.0): 47-54, nov.-dez. 2008. tab
Article in English | LILACS | ID: lil-507474

ABSTRACT

Autologous serum has been used to treat dry eye syndrome for many years. It contains several growth factors, vitamins, fibronectin and other components that have been considered important for corneal and conjunctival integrity. Serum eye drops are usually prepared as an unpreserved blood solution. The serum is by nature well tolerated and its biochemical properties are somewhat similar to natural tears. Autologous serum eye drops have been reported to be effective for the treatment of severe dry eye-related ocular surface disorders (Sjõgren's syndrome), and also other entities such as superior limbic keratoconjunctivitis, graft-versus-host disease, Stevens-Johnson syndrome, ocular cicatricial pemphigoid, recurrent or persistent corneal erosions, neurotrophic keratopathy, Mooren's ulcer, aniridic keratopathy, filtering blebs after trabeculectomy, and post-keratorefractive surgery. The purpose of this study is to review the recently published literature on ocular surface diseases treated with human autologous serum eye drops.


O soro autólogo tem sido adotado como uma nova abordagem para tratar síndrome do olho seco porque contém vitaminas, alguns fatores de crecimento e fibronectina que são considerados importantes contribuintes para integridade corneana e conjuntival. Colírio de soro autólogo é produzido sem preservativo. O soro é não-alérgico e suas propriedades bioquímicas são similares à lágrima. O soro autólogo tópico tem sido relatado efetivo para o tratamento de olho seco grave relacionado a distúrbios da superfície ocular como na síndrome de Sjõgren, ceratoconjuntivite límbica superior, doença do enxerto versus hospedeiro, síndrome de Stevens-Johnson, procedimentos cerato-refrativos, erosão corneana persistente ou recorrente, ceratopatia neurotrófica, úlcera de Mooren, ceratopatia associada à aniridia, e bolhas filtrantes após trabeculectomia. O objetivo do presente estudo é revisar a literatura recentemente publicada sobre doenças da superficie ocular tratadas com soro autológo tópico.


Subject(s)
Humans , Blood Transfusion, Autologous , Conjunctival Diseases/drug therapy , Corneal Diseases/drug therapy , Ophthalmic Solutions/therapeutic use , Serum , Dry Eye Syndromes/drug therapy , Intercellular Signaling Peptides and Proteins/therapeutic use , Serum/chemistry
10.
Arq. bras. oftalmol ; 70(5): 884-889, set.-out. 2007.
Article in English | LILACS | ID: lil-470112

ABSTRACT

PURPOSE: To report a specific line of research developed at the University of São Paulo/Brazil on fibrin glue used for sealing corneal perforations and the perspectives of use on non-perforated corneal ulcers and photorefractive keratectomy-operated corneas. METHODS: To describe fibrin glue manufacture, development of a device to test the glued perforated corneal area resistance, subsequent experimental investigations of the use of the fibrin glue in corneal perforations, reporting its efficacy, mechanical resistance experiments and histological study. Finally, the medical literature basis is searched to propose studies on the use of fibrin as a temporary basal membrane on non-perforated corneal surfaces like non-infectious corneal ulcers and on post-photorefractive keratectomy corneal surfaces. RESULTS: The development of fibrin glue, the device for resistance experiments, the efficacy, resistance and histological studies on fibrin glue used for sealing corneal perforations are reported as well as the scientific literature basis for the proposed studies on the use of fibrin as a temporary basal membrane on non-perforated corneas like non-perforated corneal ulcers and photorefractive keratectomy corneal surfaces. CONCLUSION: A specific line of research was reported on fibrin glue to seal corneal perforations at the University of São Paulo/Brazil and the theoretical perspectives for the use of fibrin in non-perforated corneal ulcers and on photorefractive keratectomy-operated corneas in an attempt to reduce corneal haze.


OBJETIVO: Relatar uma linha de pesquisa desenvolvida no Brasil (Universidade de São Paulo) em cola de fibrina para tamponamento de perfuração corneana e a perspectiva de seu uso em úlceras corneanas não perfuradas e em córneas operadas de ceratectomia fotorrefrativa. MÉTODOS: Relatar a fabricação da cola de fibrina, desenvolvimento de instrumentação para ensaio de resistência da área colada, estudo experimental da eficácia, da resistência e histológico e levantada a literatura médica para embasar proposta de estudo da cola de fibrina como membrana basal provisória sobre superfícies corneanas não perfuradas como úlceras corneanas tróficas e superfícies corneanas operadas de ceratectomia fotorrefrativa. RESULTADOS: O desenvolvimento da cola de fibrina, do equipamento para seu ensaio de resistência, os estudos experimentais de eficácia, resistência e histológico da área corneana colada com fibrina são relatados. É mostrada a base na literatura científica para a proposição de estudos com o uso de fibrina como membrana basal provisória sobre superfícies corneanas não perfuradas como úlceras tróficas e superfícies corneanas pós-ceratectomia fotorrefrativa. CONCLUSÃO: Foi relatada uma linha de pesquisa em cola de fibrina para tamponamento de perfuração corneana no Brasil (Universidade de São Paulo) e suas perspectivas teóricas de uso em úlceras corneanas não perfuradas e sobre córneas operadas de ceratectomia fotorrefrativa com intenção de reduzir "haze".


Subject(s)
Animals , Dogs , Humans , Corneal Diseases/drug therapy , Corneal Ulcer/drug therapy , Fibrin Tissue Adhesive/therapeutic use , Membranes, Artificial , Research Design , Tissue Adhesives/therapeutic use , Brazil , Cornea/injuries , Corneal Diseases/surgery , Intraocular Pressure/drug effects , Lasers, Excimer , Models, Animal , Photorefractive Keratectomy
11.
Indian J Ophthalmol ; 2007 Jan-Feb; 55(1): 55-7
Article in English | IMSEAR | ID: sea-70715

ABSTRACT

We report two siblings with the rare entity of familial calcific band-shaped keratopathy (BSK). Detailed ophthalmic and systemic investigations failed to reveal any underlying causative pathology. Topical disodium ethylenediamine-tetraacetate (EDTA) was applied for 30 min to all four eyes. In addition the right eye of the younger sibling required a superficial keratectomy. An improvement in corneal clarity was seen in the immediate postoperative period in both siblings. Histopathology of the keratectomy specimen revealed linear extracellular sub-epithelial granular calcium deposits. However, an early recurrence was noted in all four eyes at four weeks postoperatively. We report the second instance in the English literature of this entity. Band-shaped keratopathy presenting without an obvious etiology merits a complete systemic and ophthalmic workup. Patients with familial idiopathic BSK could be cases with poor prognosis for treatment with EDTA due to an early recurrence of the disease.


Subject(s)
Calcinosis/drug therapy , Chelating Agents/therapeutic use , Child , Child, Preschool , Corneal Diseases/drug therapy , Edetic Acid/therapeutic use , Female , Humans , Male , Recurrence , Time Factors , Visual Acuity
12.
Arq. bras. oftalmol ; 69(3): 407-411, maio-jun. 2006. ilus
Article in Portuguese | LILACS | ID: lil-433808

ABSTRACT

São relatados três casos de neoplasia intra-epitelial córneo-conjuntival nos quais a mitomicina C foi utilizada em abordagens distintas de acordo com a situação clínica encontrada. Os pacientes selecionados foram atendidos no Departamento de Oftalmologia da Casa de Saúde Santo Inácio, com diagnóstico clínico e/ou histopatológico de neoplasia intra-epitelial córneo-conjuntival. Com base na apresentação clínica das lesões, utilizou-se a mitomicina C a 0,04 por cento em três abordagens terapêuticas distintas: 1) quimioablação pós-operatória; 2) quimiorredução pré-operatória; e 3) quimioablação isolada. Obteve-se regressão da lesão tumoral nos três casos, sem recorrência em tempo de seguimento variando de 18-29 meses. Hiperemia conjuntival em um dos casos foi a única complicação observada. A mitomicina C mostrou-se eficaz e segura para tratamento de neoplasia intra-epitelial córneo-conjuntival, possibilitando várias abordagens terapêuticas de acordo com as características das lesões.


Subject(s)
Humans , Male , Female , Middle Aged , Aged, 80 and over , Antibiotics, Antineoplastic/administration & dosage , Carcinoma in Situ/drug therapy , Conjunctival Neoplasms/drug therapy , Corneal Diseases/drug therapy , Mitomycin/administration & dosage , Administration, Topical , Carcinoma in Situ/surgery , Conjunctival Neoplasms/surgery , Corneal Diseases/surgery , Eye Neoplasms/drug therapy , Eye Neoplasms/surgery , Follow-Up Studies , Treatment Outcome
13.
Journal of Korean Medical Science ; : 131-135, 2006.
Article in English | WPRIM | ID: wpr-71340

ABSTRACT

To determine if the involuntary contractions of eyelids may have any effects on the development of corneal astigmatism, we performed this prospective study which includes 19 patients with either essential blepharospasm or hemifacial spasm. In hemifacial spasm, the degree of corneal astigmatism was evaluated between two eyes. Then the topographic changes were checked using vector analysis technique before and after passively opening the eyelids. They were also measured before and at 1 and 6 months after the injection of Botulinum toxin. Resultantly, 20 eyes had the with-the-rule (group1) and 9 eyes against-the-rule (group2) astigmatism. In hemifacial spasm, significantly more astigmatism was found at spastic eyes. The corneal topographic changes after passively opening the eyelids showed 10 eyes with the astigmatic shift to the with-the-rule, while the remaining 19 to the againstthe- rule. At 1 month after injection of Botulinum toxin, group 1 showed reduced average corneal astigmatism, whereas group 2 showed increased astigmatism. The astigmatic change vector showed significantly more against-the-rule. In the contrary, 6 months after treatment, corneal astigmatism again increased in group 1 and decreased in group 2. So they took on the appearance of pretreatment astigmatic status eventually. Conclusively eyelids may play an important role in corneal curvature.


Subject(s)
Aged , Female , Humans , Male , Middle Aged , Astigmatism/drug therapy , Blepharospasm/drug therapy , Botulinum Toxins, Type A/administration & dosage , Cornea/drug effects , Corneal Diseases/drug therapy , Eyelids/drug effects , Injections , Time Factors , Treatment Outcome
14.
Indian J Pediatr ; 2005 Oct; 72(10): 881-2
Article in English | IMSEAR | ID: sea-83195

ABSTRACT

A 40-day-old male child was admitted with complaints of not opening eyes from 2-3 days after birth. A diagnosis of X3-B keratomalacia was made. The treatment was done with vitamin-A to which the patient had responded. The mother of the baby had a history of night blindness throughout the pregnancy for which she was also treated. Keratomalacia secondary to vitamin-A deficiency is rare in neonates, although in children it is reported form developing countries.


Subject(s)
Adult , Age Factors , Corneal Diseases/drug therapy , Corneal Opacity/etiology , Corneal Ulcer/drug therapy , Female , Humans , Infant , Male , Night Blindness/drug therapy , Photophobia/etiology , Pregnancy , Pregnancy Complications , Time Factors , Treatment Outcome , Vitamin A/administration & dosage , Vitamin A Deficiency/drug therapy
15.
Arq. bras. oftalmol ; 68(2): 270-272, mar.-abr. 2005. ilus, tab
Article in English | LILACS | ID: lil-402529

ABSTRACT

Relato de um caso atípico de infecção fúngica da córnea causada pelo microrganismo Fonsecaea pedrosoi após trauma ocular. Paciente, masculino, estudante de 18 anos, apresentou-se ao Setor de Doenças Externas Oculares do Departamento de Oftalmologia da UNIFESP com úlcera de córnea paracentral de 3,5 x 3,5 mm e aspecto branco-acinzentado com bordas infiltradas, 28 dias após trauma em ocular por vidro. Foi realizado raspado da córnea e o material enviado para análise microbiológica. Foi observado crescimento de colônias em meio de cultura e posteriormente colocadas em solução de lactofenol-azul de algodão. Verificou-se a presença de hifas dermáceas de pigmento escuro, identificado como Fonsecaea pedrosoi. Tratamento foi iniciado com natamicina 5% tópica a cada hora e cetoconazol 200 mg por dia. Subseqüentemente foi substituído pela combinação cetoconazol e anfotericina B. Fonsecaea pedrosoi é uma das principais causas em humanos de micose crônica cutânea, cromoblastomicose, em regiões úmidas tropicais. A combinação de antimicóticos sistêmicos e tópicos pode ser a melhor opção para pacientes no tratamento de cromoblastomicose da córnea.


Subject(s)
Humans , Male , Adolescent , Antifungal Agents/therapeutic use , Ascomycota/isolation & purification , Chromoblastomycosis/drug therapy , Corneal Diseases/drug therapy , Chromoblastomycosis/complications , Corneal Diseases/microbiology , Ketoconazole/therapeutic use , Natamycin/therapeutic use
17.
Journal of Korean Medical Science ; : 611-615, 2004.
Article in English | WPRIM | ID: wpr-109216

ABSTRACT

We report two cases of band keratopathy who were treated with thick amniotic membrane that contained a basement membrane structure as a graft, after ethylenediaminetetraacetic acid chelation with trephination and blunt superficial lamellar keratectomy in the anterior stroma. In each case, basement membrane was destroyed and calcium plaque invaded into anterior stroma beneath Bowman's membrane. The calcified lesions were removed surgically, resulting in a smooth ocular surface, and the fine structures of band keratopathy were confirmed by pathologic findings. After that, amniotic membrane transplantation was performed to replace the excised epithelium and stroma. Wound healing was completed within 10 days. Stable ocular surface was restored without pain or inflammation. During the mean follow-up period of 13.5 months, no recurrence of band keratopathy was observed. This combined treatment is a safe and effective method for the removal of deep-situated calcium plaque and allowing the recovery of a stable ocular surface.


Subject(s)
Female , Humans , Male , Middle Aged , Amnion/anatomy & histology , Calcium/metabolism , Chelating Agents/therapeutic use , Cornea/pathology , Corneal Diseases/drug therapy , Edetic Acid/therapeutic use
18.
Ciênc. rural ; 31(3): 553-556, maio-jun. 2001. ilus
Article in English | LILACS | ID: lil-310360

ABSTRACT

Seqüestro corneano é uma doença única dos gatos domésticos. Caracterizada clinicamente pela crônicidade, sinais de dor ocular, com desenvolvimento de placa marrom a enegrecida, opaca, de localizaçäo central ou paracentral. O propósito deste artigo de revisäo é abordar e discutir questöes sobre a etiologia, manifestaçöes clínicas, diagnóstico e tratamento da enfermidade.


Subject(s)
Animals , Cats , Cat Diseases , Corneal Diseases/diagnosis , Corneal Diseases/etiology , Corneal Diseases/drug therapy , Corneal Diseases/veterinary
19.
Indian J Pathol Microbiol ; 1997 Oct; 40(4): 549-51
Article in English | IMSEAR | ID: sea-73321

ABSTRACT

A patient from a rural background developed corneal ulceration following an insect hitting the eye. Corneal scrapings when processed for bacterial and fungal growth yielded Nigrospora, a contaminant fungus. This fungus has been quoted in literature as a common contaminant of no pathogenic significance. Herein, we describe its role as the causative agent of corneal ulcer, which has not been reported thus far.


Subject(s)
Antifungal Agents/therapeutic use , Atropine/therapeutic use , Cornea/microbiology , Corneal Diseases/drug therapy , Gentamicins/therapeutic use , Humans , Ketoconazole/therapeutic use , Male , Miconazole/therapeutic use , Middle Aged , Mitosporic Fungi/isolation & purification , Mycoses/complications , Natamycin/therapeutic use , Ulcer/drug therapy
20.
Arq. Inst. Penido Burnier ; 33(2): 109-12, jul. 1991. ilus
Article in Portuguese | LILACS | ID: lil-122043

ABSTRACT

Atrofia Essencial da Iris, Síndrome de Chandler e Síndrome de Coogan-Reese säo, atualmente, consideradas variaçöes de uma mesma patologia: Síndrome %) e seu controle é defícil. Portanto, o tratamento visa o controle da PIO e a manutençäo de uma boa acuidade visual. Os autores apresentam um caso de Síndrome de Coogan-Reese em uma paciente de 27 anos onde conseguiram restabelecer uma boa visäo através de uma pupiloplastia com Nd Yag Laser e o controle da PIO foi alcançado através do Implante de Molteno


Subject(s)
Humans , Female , Adult , Corneal Diseases/drug therapy , Iris Diseases/drug therapy , Endothelium, Corneal , Maleates/therapeutic use , Timolol/therapeutic use , Diagnosis, Differential , Corneal Diseases/diagnosis , Iris Diseases/diagnosis , Intraocular Pressure , Prostheses and Implants
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